Pegloticase - Horizon Pharma

Drug Profile

Pegloticase - Horizon Pharma

Alternative Names: KRYSTEXXA; Methoxypolyethylene glycol uricase; PEG urate oxidase; PEG-uricase; PEGylated uricase; Polyethylene glycol-uricase; Puricase; Urate-oxidase-PEG

Latest Information Update: 08 Oct 2018

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At a glance

  • Originator Duke University; Mountain View Pharmaceuticals
  • Developer Horizon Pharma Rheumatology; Savient Pharmaceuticals
  • Class Antigouts; Oxidoreductases; Polyethylene glycols; Recombinant proteins
  • Mechanism of Action Urate oxidase stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gout
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gout

Most Recent Events

  • 26 Sep 2018 Phase-II clinical trials in Gout (Combination therapy) in USA (IV) (NCT03635957)
  • 08 Aug 2018 Horizon Pharma plans the phase II MIRROR trial for Gout (In combination with methotrexate) in September 2018 (NCT03635957)
  • 15 Jun 2018 Updated efficacy data from phase III trials in Gout released by Horizon Pharma
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