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Pegloticase - Horizon Pharma

Drug Profile

Pegloticase - Horizon Pharma

Alternative Names: KRYSTEXXA; Methoxypolyethylene glycol uricase; PEG urate oxidase; PEG-uricase; PEGylated uricase; Polyethylene glycol-uricase; Puricase; Urate-oxidase-PEG

Latest Information Update: 15 Nov 2018

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At a glance

  • Originator Duke University; Mountain View Pharmaceuticals
  • Developer Horizon Pharma Rheumatology; Savient Pharmaceuticals
  • Class Antigouts; Oxidoreductases; Polyethylene glycols; Recombinant proteins
  • Mechanism of Action Urate oxidase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gout
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gout

Most Recent Events

  • 07 Nov 2018 Efficacy data from a clinical trial (external case series) in Gout (Combination therapy) released by Horizon Pharma
  • 07 Nov 2018 Horizon Pharma initiates two investigator-sponsored trials in Gout (Combination therapy with mycophenolate mofetil and azathioprine)
  • 26 Sep 2018 Phase-II clinical trials in Gout (Combination therapy) in USA (IV) (NCT03635957)
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