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Diquafosol - Merck/Santen Pharmaceutical

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Drug Profile

Diquafosol - Merck/Santen Pharmaceutical

Alternative Names: DE-089; DE-089C; Diquafosol sodium; Diquafosol tetrasodium; Diquas; Diquas ophthalmic solution; INS 365; KPY 998; Prolacria; STN-1008903

Latest Information Update: 19 Aug 2026

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At a glance

  • Originator Inspire Pharmaceuticals
  • Developer Inspire Pharmaceuticals; Meiji Seika Pharma; Santen Pharmaceutical
  • Class Alcohols; Antibronchitics; Antifibrotics; Cyclic ethers; Expectorants; Eye disorder therapies; Furans; Polyphosphates; Pyrimidinones; Small molecules; Uracil nucleotides
  • Mechanism of Action Purinoceptor P2U agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Dry eyes
  • Discontinued Bronchitis; Chronic obstructive pulmonary disease; Corneal ulcer; Cystic fibrosis

Most Recent Events

  • 01 May 2026 Preregistration for Dry eyes in Asia (Ophthalmic)
  • 28 Oct 2020 No recent reports of development identified for phase-I development in Dry-eyes in Taiwan (Ophthalmic, Liquid)
  • 28 Aug 2020 Santen Pharmaceutical initiates a phase IIIb trial in Dry eyes in Japan (JapicCTI205466)

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