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Plitidepsin - PharmaMar

Drug Profile

Plitidepsin - PharmaMar

Alternative Names: Aplidin; Aplidine; DDB; Dehydrodidemnin B

Latest Information Update: 30 Apr 2019

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At a glance

  • Originator PharmaMar
  • Class Antineoplastics; Depsipeptides
  • Mechanism of Action Apoptosis stimulants; Cell cycle inhibitors; Protein synthesis inhibitors; Vascular endothelial growth factor receptor-1 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma; Precursor cell lymphoblastic leukaemia-lymphoma
  • New Molecular Entity Yes
  • Available For Licensing Yes - Multiple myeloma; Multiple myeloma; Peripheral T-cell lymphoma

Highest Development Phases

  • Registered Multiple myeloma
  • Phase II Non-Hodgkin's lymphoma; T-cell lymphoma
  • No development reported Liposarcoma; Malignant melanoma; Myelofibrosis; Solid tumours
  • Discontinued Leukaemia; Prostate cancer

Most Recent Events

  • 01 Apr 2019 PharmaMar and Specialized Therapeutics Asia announces that approval of Aplidin® will be extended to other licensed countries, including New Zealand and South Asia
  • 11 Dec 2018 Registered for Multiple myeloma (Second-line therapy or greater, Combination therapy) in Australia (IV)
  • 20 Jul 2018 PharmaMar terminates a phase II trial in T-cell lymphoma (Second-line therapy or greater) in Czech Republic, Italy, Spain, USA (IV) (NCT03070964) (EudraCT2015-001909-14)
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