Drug Profile

Plitidepsin - PharmaMar

Alternative Names: Aplidin; Aplidine; DDB; Dehydrodidemnin B; PM90001

Latest Information Update: 28 Jul 2024

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At a glance

Originator PharmaMar
Developer Boryung Pharmaceutical; PharmaMar
Class Anti-inflammatories; Antineoplastics; Antivirals; Depsipeptides; Lactones
Mechanism of Action Apoptosis stimulants; Cell cycle inhibitors; Peptide elongation factor 1 inhibitors; Protein synthesis inhibitors; Vascular endothelial growth factor receptor-1 antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Multiple myeloma; Precursor cell lymphoblastic leukaemia-lymphoma
New Molecular Entity Yes
Available For Licensing Yes - Multiple myeloma; Multiple myeloma; Peripheral T-cell lymphoma

Marketed Multiple myeloma
Phase III COVID 2019 infections
Phase II Non-Hodgkin's lymphoma; T-cell lymphoma; Urogenital cancer
No development reported Liposarcoma; Malignant melanoma; Myelofibrosis; Solid tumours
Discontinued Leukaemia; Prostate cancer

28 Jul 2024 No recent reports of development identified for preclinical development in COVID-2019-infections in South Korea (IV)
08 Jul 2024 European Commission (EC) revokes the refusal to grant Marketing authorization for plitidepsin in Multiple myeloma
27 Apr 2024 Efficacy and adverse events data from the phase III NEPTUNO trial in COVID-2019 infections presented at the 34^th Congress of the European Society of Clinical Microbiology and Infectious (ESCMID-2024)

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