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OCX 191

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Drug Profile

OCX 191

Alternative Names: 3-AP; 3-Apct; NSC 663249; NSC#663249; NTO-1151; OCX-0191; OCX-191; Triapine

Latest Information Update: 10 Jul 2024

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At a glance

  • Originator Yale University
  • Developer National Cancer Institute (USA); National Resilience; Trethera; Vion Pharmaceuticals
  • Class Antineoplastics; Pyridines; Small molecules; Thiosemicarbazones
  • Mechanism of Action Ribonucleotide reductase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Gynaecological cancer
  • Phase II Cervical cancer; Solid tumours
  • No development reported Breast cancer; Cholangiocarcinoma; Gallbladder cancer; Haematological malignancies; Head and neck cancer; Leukaemia; Neuroendocrine tumours; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer
  • Discontinued Cancer; Cancer metastases; Hepatitis B; Herpes simplex virus infections; HIV infections

Most Recent Events

  • 31 May 2024 National Cancer Institute plans a phase II trial for Neuroendocrine tumours (PO)
  • 14 May 2024 Nanopharmaceutics in collaboration with Northwestern University plans a phase I study in Glioblastoma (second-line or greater therapy) in the US (PO) (NCT06410248)
  • 28 Jul 2023 No recent reports of development identified for phase-I development in Neuroendocrine-tumours(Combination therapy, Metastatic disease, Second-line therapy or greater) in USA (PO)

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