Tipiracil/trifluridine - Taiho Pharmaceutical

Drug Profile

Tipiracil/trifluridine - Taiho Pharmaceutical

Alternative Names: Lonsurf; Orcantas; S 95005; S 95005/TAS-102; T15, T20; T15/T20; TAS-102; TAS-102/S-95005; Tipiracil-hydrochloride/trifluridine; Trifluridine/tipiracil; Trifluridine/tipiracil hydrochloride

Latest Information Update: 16 Oct 2018

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At a glance

  • Originator Taiho Pharmaceutical
  • Developer 3SBio; Amgen; Emory University; Ipsen; Servier; Taiho Pharmaceutical; TTY Biopharm; University of Florida; University of Wisconsin-Madison
  • Class Antineoplastics; Nucleosides; Pyrimidines; Pyrrolidines; Small molecules
  • Mechanism of Action DNA synthesis inhibitors; Thymidine phosphorylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Marketed Colorectal cancer
  • Preregistration Gastric cancer
  • Phase II Oesophageal cancer; Pancreatic cancer; Small cell lung cancer
  • Phase I/II Gastrointestinal cancer
  • Phase I Neuroendocrine tumours
  • No development reported Solid tumours

Most Recent Events

  • 01 Oct 2018 Jeil Pharmaceutical plans to launch tipiracil/trifluridine in South Korea
  • 21 Aug 2018 Taiho Pharmaceutical re-initiates in a phase I trial in Neuroendocrine tumours (Metastatic disease, Combination therapy) in USA (PO) (NCT02943733)
  • 17 Aug 2018 Preregistration for Gastric cancer (Adjunctive treatment, Metastatic disease, Second-line therapy or greater, Inoperable/Unresectable, Late-stage disease) in Japan (PO)
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