Tipiracil/trifluridine - Taiho Pharmaceutical

Drug Profile

Tipiracil/trifluridine - Taiho Pharmaceutical

Alternative Names: Lonsurf; Orcantas; S 95005; S 95005/TAS-102; T15, T20; T15/T20; TAS-102; TAS-102/S-95005; Tipiracil-hydrochloride/trifluridine; Trifluridine/tipiracil; Trifluridine/tipiracil hydrochloride

Latest Information Update: 19 Apr 2018

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At a glance

  • Originator Taiho Pharmaceutical
  • Developer 3SBio; Emory University; Ipsen; Servier; Taiho Pharmaceutical; University of Florida; University of Wisconsin-Madison
  • Class Antineoplastics; Nucleosides; Pyrimidines; Pyrrolidines; Small molecules
  • Mechanism of Action DNA synthesis inhibitors; Thymidine phosphorylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Marketed Colorectal cancer
  • Phase III Gastric cancer
  • Phase II Oesophageal cancer; Pancreatic cancer; Small cell lung cancer
  • Phase I/II Gastrointestinal cancer
  • Phase I Neuroendocrine tumours
  • No development reported Solid tumours

Most Recent Events

  • 31 Mar 2018 Takeda completes the phase I/II APOLLON trial in Colorectal cancer (Combination therapy, Second-line therapy or greater, Metastatic disease) in Japan (PO) (NCT02613221)
  • 06 Mar 2018 Registered for Colorectal cancer (Refractory metastatic disease) in Canada (PO)
  • 22 Feb 2018 Launched for Colorectal cancer (Inoperable/Unresectable, Late-stage disease, Recurrent, Refractory metastatic disease) in Saudi Arabia, Lebanon, Kuwait, Argentina (PO) before February 2018
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