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Neflamapimod - CervoMed

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Drug Profile

Neflamapimod - CervoMed

Alternative Names: VX-745

Latest Information Update: 20 Dec 2024

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At a glance

  • Originator Vertex Pharmaceuticals
  • Developer CervoMed; Vertex Pharmaceuticals
  • Class 2 ring heterocyclic compounds; Anti-inflammatories; Antidementias; Benzene derivatives; Chlorobenzenes; Fluorobenzenes; Nootropics; Pyridazines; Pyrimidinones; Small molecules; Sulfides
  • Mechanism of Action P38 mitogen-activated protein kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Frontotemporal dementia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease; Huntington's disease; Lewy body disease
  • Phase I Frontotemporal dementia; Stroke
  • Discontinued Asthma; Crohn's disease; Rheumatoid arthritis

Most Recent Events

  • 20 Dec 2024 Chemical structure information added.
  • 10 Dec 2024 Efficacy and adverse events data from a phase IIb trial in Lewy body disease released by CervoMed
  • 27 Nov 2024 Neflamapimod receives Orphan Drug status for Frontotemporal dementia in USA

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