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Neflamapimod - CervoMed

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Drug Profile

Neflamapimod - CervoMed

Alternative Names: VX-745

Latest Information Update: 14 Jun 2024

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At a glance

  • Originator Vertex Pharmaceuticals
  • Developer CervoMed; Vertex Pharmaceuticals
  • Class Anti-inflammatories; Antidementias; Nootropics; Pyridazines; Small molecules; Sulfides
  • Mechanism of Action P38 mitogen-activated protein kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease; Huntington's disease; Lewy body disease
  • Phase I Frontotemporal dementia; Stroke
  • Discontinued Asthma; Crohn's disease; Rheumatoid arthritis

Most Recent Events

  • 12 Jun 2024 CervoMed completes enrolment in the Phase-IIb RewinD-LB trial in Lewy body disease in USA (PO) (NCT05869669)
  • 15 May 2024 CervoMed plans a cliical trial of neflamapimod in cholinergic dysfunction driven Neurological disorders
  • 10 Apr 2024 CervoMed plans a phase III trial for Lewy body disease in the mid of 2025

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