Imetelstat - Geron Corporation

Drug Profile

Imetelstat - Geron Corporation

Alternative Names: GRN 140719; GRN 163; GRN 163-L; GRN 719; GRN163L peptide; Imetelstat sodium; JNJ-63935937

Latest Information Update: 12 Nov 2018

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At a glance

  • Originator Geron Corporation
  • Developer Geron Corporation; Janssen Biotech
  • Class Antineoplastics; Oligonucleotides; Oligopeptides
  • Mechanism of Action Telomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelofibrosis; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Myelodysplastic syndromes
  • Phase II Myelofibrosis
  • Preclinical Acute myeloid leukaemia; Chronic myeloid leukaemia
  • Suspended Multiple myeloma
  • Discontinued Breast cancer; Essential thrombocythaemia; Lymphoproliferative disorders; Non-small cell lung cancer; Polycythaemia vera; Solid tumours

Most Recent Events

  • 01 Nov 2018 Geron Corporation intends to seek a discussion with the regulatory authorities and myelofibrosis experts regarding the results of the IMbark primary analysis and overall survival
  • 01 Nov 2018 Geron Corporation plans a clinical trial for Myelofibrosis (Second line therapy or greater)
  • 01 Nov 2018 Geron Corporation plans the phase III portion of IMerge trial for Myelodysplastic syndrome by mid of 2019
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