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Sapacitabine - Daiichi Sankyo Company

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Drug Profile

Sapacitabine - Daiichi Sankyo Company

Alternative Names: CS-682; CYC-682

Latest Information Update: 08 Jun 2023

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At a glance

  • Originator Daiichi Sankyo Company; Hokkaido University; Kanazawa University
  • Developer Cyclacel Pharmaceuticals; Leukaemia & Lymphoma Research; University of Texas M. D. Anderson Cancer Center
  • Class Amides; Antineoplastics; Arabinonucleosides; Pyrimidines; Small molecules
  • Mechanism of Action Antimetabolites; Cell cycle inhibitors; DNA-directed DNA polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelodysplastic syndromes; Acute myeloid leukaemia
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Breast cancer; Chronic lymphocytic leukaemia; Cutaneous T-cell lymphoma; Myelodysplastic syndromes; Non-small cell lung cancer; Ovarian cancer; Precursor B-cell lymphoblastic leukaemia-lymphoma; Solid tumours

Most Recent Events

  • 14 Apr 2023 Safety, efficacy and pharmacodynamics data froma phase Ib/II trial in Breast cancer presented at 114th Annual Meeting of the American Association for Cancer Research (AACR-2023)
  • 23 Mar 2023 Cyclacel Pharmaceuticals terminates its licence for sapacitabine with Daiichi Sankyo
  • 09 Nov 2022 Cyclacel Pharmaceuticals plans to terminate license agreement with Daiichi Sankyo in March 2023

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