Sapacitabine - Cyclacel Pharmaceuticals

Drug Profile

Sapacitabine - Cyclacel Pharmaceuticals

Alternative Names: CS-682; CYC-682

Latest Information Update: 20 Apr 2018

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At a glance

  • Originator Daiichi Sankyo Company; Hokkaido University; Kanazawa University
  • Developer Cyclacel Pharmaceuticals; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Arabinonucleosides; Small molecules
  • Mechanism of Action Antimetabolites; DNA-directed DNA polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelodysplastic syndromes; Acute myeloid leukaemia
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Chronic lymphocytic leukaemia; Myelodysplastic syndromes; Non-small cell lung cancer
  • Phase I/II Solid tumours
  • No development reported Ovarian cancer
  • Discontinued Cutaneous T cell lymphoma

Most Recent Events

  • 05 Apr 2018 Cyclacel Pharmaceuticals terminates a phase II trial due to accrual not met in Chronic lymphocytic leukaemia (Combination therapy, Second-line therapy or greater) in USA (PO) (NCT01253460)
  • 28 Mar 2018 Cyclacel Pharmaceuticals plans a phase Ib/II trial for Breast cancer (Combination therapy) (PO), in 2018
  • 21 Feb 2018 Cyclacel Pharmaceuticals has patent protection for pharmaceutical formulations of sapacitabine in USA
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