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Sapacitabine - Cyclacel Pharmaceuticals

Drug Profile

Sapacitabine - Cyclacel Pharmaceuticals

Alternative Names: CS-682; CYC-682

Latest Information Update: 11 Oct 2018

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At a glance

  • Originator Daiichi Sankyo Company; Hokkaido University; Kanazawa University
  • Developer Cyclacel Pharmaceuticals; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Arabinonucleosides; Small molecules
  • Mechanism of Action Cell cycle inhibitors; DNA-directed DNA polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelodysplastic syndromes; Acute myeloid leukaemia
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Chronic lymphocytic leukaemia; Myelodysplastic syndromes; Non-small cell lung cancer
  • Phase I/II Breast cancer; Solid tumours
  • No development reported Ovarian cancer
  • Discontinued Cutaneous T cell lymphoma

Most Recent Events

  • 04 Oct 2018 Cyclacel Pharmaceuticals and MD Anderson Cancer Center enter into a three-year clinical collaboration agreement in Haematological Malignancies
  • 04 Oct 2018 Cyclacel Pharmaceuticals and MD Anderson Cancer Center plan a clinical trial in Haematological Malignancies (Combination therapy, Monotherapy) in USA
  • 10 Sep 2018 Phase-I/II clinical trials in Breast cancer (Combination therapy, Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater) in USA (PO) (NCT03641755)
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