Drug Profile

Leronlimab - CytoDyn

Alternative Names: PA-14; PRO-140; Vyrologix^®

Latest Information Update: 16 Jun 2026

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At a glance

Originator Progenics Pharmaceuticals
Developer CytoDyn; Progenics Pharmaceuticals; Syneos Health; Weill Cornell Medicine
Class Anti-inflammatories; Antidementias; Antineoplastics; Antiretrovirals; Antivirals; Hepatoprotectants; Immunotherapies; Monoclonal antibodies; Vascular disorder therapies
Mechanism of Action CCR5 receptor antagonists; Virus internalisation inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Graft-versus-host disease
New Molecular Entity Yes

Registered Triple negative breast cancer
Preregistration COVID 2019 infections; HIV infections
Phase II Alzheimer's disease; Colorectal cancer; Inflammation; Non-alcoholic steatohepatitis; Post acute COVID 19 syndrome; Solid tumours
Preclinical Glioblastoma
Suspended COVID-19 pneumonia
Discontinued Graft-versus-host disease; HIV-1 infections; Multiple sclerosis; Stroke; Traumatic brain injuries

30 Apr 2026 Phase-II clinical trials in Alzheimer's disease (Early-stage disease) in USA (SC) (NCT07553338)
28 Apr 2026 Weill Medical College of Cornell University plans phase II SALIENT-AD trial in Alzheimer's Disease in US (Parenteral) (NCT07553338)
22 Apr 2026 Preliminary efficacy, safety and pharmacodynamics data from the phase II CLOVER trial in Colorectal cancer released by CytoDyn

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