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Leronlimab - CytoDyn

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Drug Profile

Leronlimab - CytoDyn

Alternative Names: PA-14; PRO-140; Vyrologix®

Latest Information Update: 20 Dec 2024

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At a glance

  • Originator Progenics Pharmaceuticals
  • Developer CytoDyn; Progenics Pharmaceuticals
  • Class Anti-inflammatories; Antidementias; Antineoplastics; Antiretrovirals; Antivirals; Hepatoprotectants; Immunotherapies; Monoclonal antibodies; Vascular disorder therapies
  • Mechanism of Action CCR5 receptor antagonists; Virus internalisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Graft-versus-host disease
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Triple negative breast cancer
  • Preregistration COVID 2019 infections; HIV infections
  • Phase II Inflammation; Non-alcoholic steatohepatitis; Post acute COVID 19 syndrome; Solid tumours
  • Phase I Alzheimer's disease
  • Preclinical Glioblastoma
  • Suspended COVID-19 pneumonia
  • Discontinued Graft-versus-host disease; HIV-1 infections; Multiple sclerosis; Stroke; Traumatic brain injuries

Most Recent Events

  • 17 Dec 2024 Pharmacodynamics data from preclinical trial in Non-alcoholic steatohepatitis released by CytoDyn
  • 17 Dec 2024 CytoDyn in collaboration with American Foundation for AIDS Research plans LATCH study for HIV infections in Germany, in 2025
  • 17 Dec 2024 CytoDyn in collaboration with Syneos Health plans a phase II trial for Colorectal cancer (Combination therapy, Second-line therapy or greater, Inoperable/Unresectable, Metastatic disease) in February 2025 (NCT06699836)

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