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Leronlimab - CytoDyn

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Drug Profile

Leronlimab - CytoDyn

Alternative Names: PA-14; PRO-140; Vyrologix®

Latest Information Update: 30 Apr 2026

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At a glance

  • Originator Progenics Pharmaceuticals
  • Developer CytoDyn; Progenics Pharmaceuticals; Syneos Health
  • Class Anti-inflammatories; Antidementias; Antineoplastics; Antiretrovirals; Antivirals; Hepatoprotectants; Immunotherapies; Monoclonal antibodies; Vascular disorder therapies
  • Mechanism of Action CCR5 receptor antagonists; Virus internalisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Graft-versus-host disease
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Triple negative breast cancer
  • Preregistration COVID 2019 infections; HIV infections
  • Phase II Colorectal cancer; Inflammation; Non-alcoholic steatohepatitis; Post acute COVID 19 syndrome; Solid tumours
  • Phase I Alzheimer's disease
  • Preclinical Glioblastoma
  • Suspended COVID-19 pneumonia
  • Discontinued Graft-versus-host disease; HIV-1 infections; Multiple sclerosis; Stroke; Traumatic brain injuries

Most Recent Events

  • 22 Apr 2026 Preliminary efficacy, safety and pharmacodynamics data from the phase II CLOVER trial in Colorectal cancer released by CytoDyn
  • 21 Apr 2026 Preliminary pharmacodynamics data from a phase II CLOVER trial in Colorectal cancer released by CytoDyn
  • 21 Apr 2026 CytoDyn completes enrolment in its phase-II CLOVER clinical trial in Colorectal cancer (Combination therapy, Second-line therapy or greater, Inoperable/Unresectable, Metastatic disease) in USA (Parenteral) (NCT06699836)

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