Ranibizumab - Novartis Ophthalmics

Drug Profile

Ranibizumab - Novartis Ophthalmics

Alternative Names: AMD Fab; Anti-VEGF fragment; Lucentis; Rabinismab; RG-3645; rhuFab V2; rhuFab V2 AMD; VEGF antibody fragment

Latest Information Update: 30 Jul 2018

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At a glance

  • Originator Genentech
  • Developer Genentech; Manhattan Eye, Ear & Throat Hospital; Novartis Ophthalmics; University of Bonn
  • Class Eye disorder therapies; Monoclonal antibodies
  • Mechanism of Action Angiogenesis inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Choroidal neovascularisation; Degenerative myopia; Diabetic macular oedema; Retinal oedema; Wet age-related macular degeneration
  • Registered Diabetic retinopathy
  • Phase III Retinopathy of prematurity
  • Phase I/II Polypoidal choroidal vasculopathy
  • Discontinued Retinal telangiectasis

Most Recent Events

  • 26 Jul 2018 Interim positive top-line efficacy data from a phase II LADDER trial in Wet age-related macular degeneration released by Roche and Genentech
  • 25 Jul 2018 Roche and Genentech plans a pivotal phase III trial of Port Delivery System implant of ranibizumab for Wet age-related macular degeneration in 2018
  • 21 Mar 2018 Genentech plans to launch ranibizumab injection 0.3mg prefilled syringe for Diabetic retinopathy and Diabetic macular oedema in USA in the second quarter of 2018
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