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Ranibizumab - Genentech/Novartis Ophthalmics

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Drug Profile

Ranibizumab - Genentech/Novartis Ophthalmics

Alternative Names: ACCENTRIX; AMD Fab; Anti-VEGF fragment; Lucentis; Rabinismab; RG-3645; RG-6321; rhuFab V2; rhuFab V2 AMD; Susvimo; SusvimoTM; VEGF antibody fragment

Latest Information Update: 23 Jul 2024

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At a glance

  • Originator Genentech
  • Developer Genentech; Novartis Ophthalmics; Roche
  • Class Eye disorder therapies; Immunoglobulin fragments; Monoclonal antibodies
  • Mechanism of Action Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Retinopathy of prematurity; Wet age-related macular degeneration
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Choroidal neovascularisation; Degenerative myopia; Diabetic macular oedema; Diabetic retinopathy; Retinal oedema; Retinopathy of prematurity; Wet age-related macular degeneration
  • Phase I/II Polypoidal choroidal vasculopathy
  • Discontinued Retinal telangiectasis

Most Recent Events

  • 18 Jul 2024 Preregistration for Diabetic macular oedema in USA (Intraocular)
  • 18 Jul 2024 Preregistration for Diabetic retinopathy in USA (Intraocular)
  • 18 Jul 2024 US FDA accepts sBLA for ranibizumab for the treatment of Diabetic retinopathy and Diabetic macular oedema in USA (Intraocular, Implant)

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