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Ranibizumab - Novartis Ophthalmics

Drug Profile

Ranibizumab - Novartis Ophthalmics

Alternative Names: AMD Fab; Anti-VEGF fragment; Lucentis; Rabinismab; RG-3645; rhuFab V2; rhuFab V2 AMD; VEGF antibody fragment

Latest Information Update: 18 Feb 2019

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At a glance

  • Originator Genentech
  • Developer Genentech; Manhattan Eye, Ear & Throat Hospital; Novartis Ophthalmics; University of Bonn
  • Class Eye disorder therapies; Monoclonal antibodies
  • Mechanism of Action Angiogenesis inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Choroidal neovascularisation; Degenerative myopia; Diabetic macular oedema; Retinal oedema; Wet age-related macular degeneration
  • Registered Diabetic retinopathy
  • Phase III Retinopathy of prematurity
  • Phase I/II Polypoidal choroidal vasculopathy
  • Discontinued Retinal telangiectasis

Most Recent Events

  • 22 Sep 2018 Novartis announces intention to submit regulatory filings for marketing approval of Ranibizumab in Retinopathy of prematurity outside USA
  • 22 Sep 2018 Efficacy data from the phase III RAINBOW trial in Retinopathy of prematurity (In infants) released by Novartis
  • 21 Sep 2018 Roche initiates enrolment in a phase III trial of Port Delivery System (PDS) with ranibizumab for Neovascular age-related macular degeneration in the US (NCT03683251)
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