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I-131-Apamistamab - Actinium Pharmaceuticals

Drug Profile

I-131-Apamistamab - Actinium Pharmaceuticals

Alternative Names: 131-I-labeled anti-CD45 antibody; 131-I-labeled BC8 antibody; 131I-BC8 (anti-CD45) antibody - Actinium Pharmaceuticals; Anti-CD45 monoclonal antibody-BC8-I-131; Anti-CD45 monoclonal antibody-I-131; BC 8; BC8-I-131 construct; I-131-BC8; I131-Apamistamab; Iodine I 131 Apamistamab; Iodine-131-apamistamab; Iomab-ACT; Iomab-B

Latest Information Update: 04 Apr 2024

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At a glance

  • Originator Fred Hutchinson Cancer Research Center
  • Developer Actinium Pharmaceuticals; Fred Hutchinson Cancer Research Center; Memorial Sloan-Kettering Cancer Center
  • Class Antineoplastics; Immunoconjugates; Iodine radioisotopes; Monoclonal antibodies; Radiopharmaceuticals
  • Mechanism of Action Ionising radiation emitters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Myelodysplastic syndromes; Precursor cell lymphoblastic leukaemia-lymphoma
  • No development reported Diffuse large B cell lymphoma; Hodgkin's disease; Non-Hodgkin's lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 04 Apr 2024 Actinium Pharmaceuticals announces intention to submit MAA to European Medicines Agency for Acute myeloid leukemia in 2024 and anticipates approval in 2025
  • 03 Apr 2024 Actinium Pharmaceuticals plans a clinical trial of I-131 apamistamab as a targeted conditioning agent prior to CAR T-cell therapy
  • 28 Mar 2024 No recent reports of development identified for phase-I development in Diffuse large B cell lymphoma(Combination therapy, In the elderly, Second-line therapy or greater, In adults) in USA (IV, Infusion)
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