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Vosaroxin - Denovo Biopharma/Sumitomo Pharma

Drug Profile

Vosaroxin - Denovo Biopharma/Sumitomo Pharma

Alternative Names: AG-7352; AG-7352 hydrochloride; DB 106; QINPREZO; SNS-595; SPC-595; Voreloxin

Latest Information Update: 17 May 2024

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At a glance

  • Originator Dainippon Sumitomo Pharma
  • Developer Cardiff University; Sunesis Pharmaceuticals; University of Texas M. D. Anderson Cancer Center; Vanderbilt-Ingram Cancer Center; Viracta Therapeutics; Washington University School of Medicine; Weill Cornell Medical College
  • Class Antineoplastics; Carboxylic acids; Naphthyridines; Pyrrolidines; Quinolones; Small molecules; Thiazoles
  • Mechanism of Action DNA intercalators; Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II/III Myelodysplastic syndromes; Precursor B-cell lymphoblastic leukaemia-lymphoma
  • No development reported Glioblastoma
  • Discontinued Non-small cell lung cancer; Ovarian cancer; Small cell lung cancer

Most Recent Events

  • 29 Apr 2024 Sunesis Pharmaceuticals completed phase-I trials in Myelodysplastic syndromes (Combination therapy, Second-line therapy or greater) in USA (IV) (NCT01913951)
  • 02 Jan 2023 Vosaroxin is still in phase-II/III trials for Precursor B-cell lymphoblastic leukaemia-lymphoma in Denmark (IV)(EudraCT2011-000749-19)
  • 02 Jan 2023 No development reported - Phase-II for Acute myeloid leukaemia (Combination therapy, In the elderly, Newly diagnosed) in Germany (IV) (Denovo Biopharma pipeline; January 2022).
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