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Sorafenib - Bayer

Drug Profile

Sorafenib - Bayer

Alternative Names: BAY 43-9006 Tosylate; BAY 54-9085; BAY-43-9006; BAY-439006-Tosylate-Salt; Nexavar; Sorafenib tosilate; Sorafenib tosylate

Latest Information Update: 09 Sep 2019

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At a glance

  • Originator Onyx Pharmaceuticals; University of Kentucky
  • Developer ACORN Research; Asan Medical Center; Bayer; Beth Israel Deaconess Medical Center; Charite of Berlin; Genentech; Indiana University; Indiana University School of Medicine; Karolinska University Hospital; Memorial Sloan-Kettering Cancer Center; Merck Sharp & Dohme; National Cancer Center (Korea); National Cancer Institute (USA); Onyx Pharmaceuticals; Oregon Health & Science University; Takeda; Thomas Jefferson University; University of California, San Diego; University of Texas M. D. Anderson Cancer Center; Yale University
  • Class Amides; Antineoplastics; Benzenesulfonates; Chlorobenzenes; Pyridines; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; Fms-like tyrosine kinase 3 inhibitors; Mitogen-activated protein kinase inhibitors; Mitogen-activated protein kinase kinase inhibitors; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein b raf inhibitors; Proto oncogene protein c ret inhibitors; Proto oncogene protein c-kit inhibitors; Proto oncogene proteins c raf inhibitors; Raf kinase inhibitors; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thyroid cancer; Liver cancer; Renal cell carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Liver cancer; Renal cell carcinoma; Thyroid cancer
  • Phase II Acute myeloid leukaemia; Chronic lymphocytic leukaemia; Gastric cancer; Glioma; Head and neck cancer; Myelodysplastic syndromes; Neurofibromatoses; Oesophageal cancer; Ovarian cancer; Portal hypertension; Soft tissue sarcoma
  • Phase I Cancer; Glioblastoma; Gliosarcoma; Urogenital cancer
  • Suspended Malignant melanoma; Prostate cancer
  • No development reported Acute promyelocytic leukaemia; Colorectal cancer; Germ cell and embryonal neoplasms; Mesothelioma; Neuroendocrine tumours; Pancreatic cancer; Solid tumours
  • Discontinued Breast cancer; Non-small cell lung cancer; Small cell lung cancer

Most Recent Events

  • 07 Dec 2018 No development reported - Phase-II for Mesothelioma (Second-line therapy or greater) in United Kingdom (PO)
  • 06 Dec 2018 Bayer terminates phase II trial in Acute myeloid leukaemia in Austria and Germany (EudraCT 2010-018539-16)
  • 01 Dec 2018 Safety and efficacy data from the phase II SORMAIN trial in Acute myeloid leukaemia presented at the 60th Annual Meeting and Exposition of the American Society of Hematology (ASH-2018)
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