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Iopofosine I 131 - Cellectar Biosciences

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Drug Profile

Iopofosine I 131 - Cellectar Biosciences

Alternative Names: (131)I-CLR1404; 131-I-NM404; 131I-CLR1404; CLR 1404 I-131; CLR-131; HOT; I-131-CLR1404; NM-404

Latest Information Update: 10 Apr 2024

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At a glance

  • Originator University of Michigan Medical School
  • Developer Cellectar Biosciences; University of Wisconsin-Madison
  • Class Antineoplastics; Drug conjugates; Iodine radioisotopes; Phospholipid ethers; Radiopharmaceuticals; Small molecules
  • Mechanism of Action Ionising radiation emitters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Rhabdomyosarcoma; Neuroblastoma; Osteosarcoma; Multiple myeloma; Ewing's sarcoma; Waldenstrom's macroglobulinaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Haematological malignancies; Multiple myeloma; Waldenstrom's macroglobulinaemia
  • Phase I/II Non-small cell lung cancer
  • Phase I Brain cancer; Glioma; Head and neck cancer; Lymphoma; Solid tumours

Most Recent Events

  • 27 Mar 2024 Cellectar Biosciences announces intention to submit NDA for Waldenstrom’s macroglobulinemia in March 2024
  • 27 Mar 2024 Cellectar Biosciences plans to request accelerated approval for Waldenstrom’s macroglobulinemia
  • 27 Mar 2024 Efficacy data from a phase I trial in Head and neck cancer released by Cellectar Biosciences
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