Drug Profile


Alternative Names: CCI-779; Cell cycle inhibitor-779; NSC-683864; Torisel

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Wyeth
  • Developer Johann Wolfgang Goethe Universitatsklinikum; Multiple Myeloma Research Consortium; NCIC Clinical Trials Group; Pfizer; Wyeth
  • Class Antineoplastics; Macrolides
  • Mechanism of Action MTOR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Renal cell carcinoma; Mantle-cell lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Marketed Mantle-cell lymphoma; Renal cell carcinoma
  • Phase II Acute myeloid leukaemia; Bladder cancer; Glioblastoma; Glioma; Hodgkin's disease; Non-Hodgkin's lymphoma
  • Phase I/II Follicular lymphoma; Head and neck cancer
  • Phase I Lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma; Solid tumours
  • No development reported Colorectal cancer; Multiple myeloma; Prostate cancer
  • Discontinued Breast cancer; Pancreatic cancer; Soft tissue sarcoma

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Colorectal-cancer in USA (IV, Infusion)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Glioblastoma(Combination therapy, Metastatic disease) in Germany (IV, Infusion)
  • 19 Sep 2017 Johannes Gutenberg University Mainz and Pfizer completes a phase I/II trial in Follicular lymphoma or Mantle cell lymphoma in Germany (NCT01078142)
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