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1018 ISS

Drug Profile

1018 ISS

Alternative Names: First generation 1018 ISS - Dynavax; ISS 1018; ISS DNA; ISS1; ISS2

Latest Information Update: 16 Oct 2013

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At a glance

  • Originator Dynavax Technologies
  • Developer Dana-Farber Cancer Institute; Dynavax Technologies
  • Class DNA; Oligonucleotides
  • Mechanism of Action Immunostimulants; Toll-like receptor 9 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Suspended Allergic asthma
  • Discontinued Colorectal cancer; Human papillomavirus infections; Non-Hodgkin's lymphoma

Most Recent Events

  • 16 Apr 2008 Discontinued - Preclinical for Human papillomavirus infections in USA (unspecified route)
  • 08 Jan 2007 Data presented at the 48th Annual Meeting and Exposition of the American Society of Hematology (ASH-2006) added to the adverse events section
  • 30 Nov 2006 Phase-I clinical trials in Colorectal cancer (combination therapy, second-line therapy or greater) in USA (SC) (NCT00403052)
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