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Istaroxime - Windtree Therapeutics

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Drug Profile

Istaroxime - Windtree Therapeutics

Alternative Names: Debio 0614; ISTA; PST-2744; ST-2744

Latest Information Update: 13 Aug 2025

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At a glance

  • Originator sigma-tau SpA
  • Developer sigma-tau SpA; Windtree Therapeutics
  • Class Amines; Androstanes; Cardiovascular therapies; Cyclopentanes; Heart failure therapies; Imines; Ketosteroids; Oximes; Phenanthrenes; Small molecules
  • Mechanism of Action Sarcoplasmic reticulum calcium-transporting ATPase stimulants; Sodium-potassium-exchanging ATPase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Acute heart failure; Cardiogenic shock; Decompensated heart failure

Most Recent Events

  • 05 Aug 2025 Efficacy and adverse event data from a phase I/II Seismic C trial in Cardiogenic shock released by Windtree Therapeutics
  • 02 Jul 2025 Windtree Therapeutics has patent protection for Istaroxime-containing intravenous formulations for the treatment of Heart failure in USA
  • 30 Jun 2025 Phase-I/II clinical trials in Cardiogenic shock (In the elderly, In adults) in Europe, USA, Latin America (IV), prior to June 2025

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