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Istaroxime - Windtree Therapeutics

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Drug Profile

Istaroxime - Windtree Therapeutics

Alternative Names: Debio 0614; ISTA; PST-2744; ST-2744

Latest Information Update: 20 May 2025

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At a glance

  • Originator sigma-tau SpA
  • Developer sigma-tau SpA; Windtree Therapeutics
  • Class Amines; Androstanes; Cardiovascular therapies; Cyclopentanes; Heart failure therapies; Imines; Ketosteroids; Oximes; Phenanthrenes; Small molecules
  • Mechanism of Action Sarcoplasmic reticulum calcium-transporting ATPase stimulants; Sodium-potassium-exchanging ATPase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Acute heart failure; Cardiogenic shock; Decompensated heart failure

Most Recent Events

  • 12 May 2025 Pharmacodynamics data from preclinical studies in Acute-heart-failure released by Windtree Therapeutics
  • 15 Apr 2025 Windtree Therapeutics plans regulatory discussions in early 2026
  • 15 Apr 2025 Windtree Therapeutics plans to initiate phase III trial in Acute heart failure in first half of 2025.

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