Gemcabene - Gemphire Therapeutics

Drug Profile

Gemcabene - Gemphire Therapeutics

Alternative Names: CI-1027; Gemcabene calcium; PD 0072953; PD 072953

Latest Information Update: 21 Aug 2018

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At a glance

  • Originator Pfizer
  • Developer Emory University; Gemphire Therapeutics; Pfizer
  • Class Antihyperlipidaemics; Caproates; Small molecules
  • Mechanism of Action Acetyl-CoA carboxylase inhibitors; Apolipoprotein C-III inhibitors; C-reactive protein inhibitors; CCR2 receptor antagonists; CCR5 receptor antagonists; Lipoprotein A inhibitors; Sulfatase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypercholesterolaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hypercholesterolaemia; Hyperlipoproteinaemias; Hypertension; Hypertriglyceridaemia; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Osteoarthritis

Most Recent Events

  • 08 Nov 2018 Gemphire Therapeutics plans an end of phase II meeting with the US FDA in 2019
  • 13 Aug 2018 USFDA requested Gemphire Therapeutics to provide additional data regarding the partial clinical hold
  • 10 Aug 2018 Emory University and Gemphire Therapeutics terminate phase II trial in Non-alcoholic fatty liver disease (In adolescents) in USA
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