Entinostat - Syndax Pharmaceuticals

Drug Profile

Entinostat - Syndax Pharmaceuticals

Alternative Names: EDP-103; Entinostat; KHK-2375; MS-27-275; MS-275; SNDX-275

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Nihon Schering; Pfizer; University of Tokyo
  • Developer Columbia University; Eddingpharm; Genentech; Indiana University; Kyowa Hakko Kirin; Memorial Sloan-Kettering Cancer Center; Merck & Co; National Cancer Institute (USA); Pfizer; Roswell Park Cancer Institute; Syndax Pharmaceuticals
  • Class Antineoplastics; Benzamides; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Cholangiocarcinoma; Colorectal cancer; Endometrial cancer; Follicular lymphoma; Hodgkin's disease; Leukaemia; Malignant melanoma; Neuroendocrine tumours; Non-small cell lung cancer; Pancreatic cancer; Uveal melanoma
  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Renal cell carcinoma

Most Recent Events

  • 17 Apr 2018 Prometheus Laboratories in collaboration with Syndax Pharmaceuticals plans a phase II trial for Renal Cell Carcinoma (Late-stage disease) in USA (NCT03501381)
  • 22 Mar 2018 Syndax Pharmaceuticals plans the Breast 49 phase I study for Breast Cancer (Metastatic disease, Late-stage disease) in August 2018 (NCT03473639)
  • 10 Jan 2018 Syndax Pharmaceuticals and Genentech collaborated to conduct a phase Ib/II trial for Breast cancer
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