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Entinostat - Syndax Pharmaceuticals

Drug Profile

Entinostat - Syndax Pharmaceuticals

Alternative Names: EDP-103; Entinostat; KHK-2375; MS-27-275; MS-275; SND 275; SNDX-275

Latest Information Update: 30 Oct 2019

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At a glance

  • Originator Nihon Schering; Pfizer; University of Tokyo
  • Developer Bristol-Myers Squibb; Columbia University; Eddingpharm; Genentech; Hoosier Cancer Research Network; Indiana University; Kyowa Kirin; Memorial Sloan-Kettering Cancer Center; Merck & Co; National Cancer Institute (USA); Pfizer; Syndax Pharmaceuticals; UNC Lineberger Comprehensive Cancer Center
  • Class Antineoplastics; Benzamides; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Bladder cancer; Cholangiocarcinoma; Colorectal cancer; Endometrial cancer; Follicular lymphoma; Hodgkin's disease; Leukaemia; Malignant melanoma; Neuroendocrine tumours; Non-small cell lung cancer; Pancreatic cancer; Renal cell carcinoma; Uveal melanoma
  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase I Solid tumours

Most Recent Events

  • 01 Aug 2019 Phase-II clinical trials in Bladder cancer (Combination therapy, Neoadjuvant therapy) in USA (PO) (NCT03978624)
  • 07 Jun 2019 UNC Lineberger Comprehensive Cancer Center plans a phase II trial for Bladder cancer (Combination therapy, In adults, In elderly) in June 2019 (NCT03978624)
  • 24 Apr 2019 National Cancer Institute plans a phase I trial for Solid tumours and Lymphomas (Combination therapy, Late-stage disease, Second line therapy or greater) in May 2019 (PO) (NCT03925428)
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