Entinostat - Syndax Pharmaceuticals

Drug Profile

Entinostat - Syndax Pharmaceuticals

Alternative Names: EDP-103; Entinostat; KHK-2375; MS-27-275; MS-275; SND 275; SNDX-275

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Nihon Schering; Pfizer; University of Tokyo
  • Developer Bristol-Myers Squibb; Columbia University; Eddingpharm; Genentech; Hoosier Cancer Research Network; Indiana University; Kyowa Hakko Kirin; Memorial Sloan-Kettering Cancer Center; Merck & Co; National Cancer Institute (USA); Pfizer; Syndax Pharmaceuticals; UNC Lineberger Comprehensive Cancer Center
  • Class Antineoplastics; Benzamides; Small molecules
  • Mechanism of Action Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Cholangiocarcinoma; Colorectal cancer; Endometrial cancer; Follicular lymphoma; Hodgkin's disease; Leukaemia; Malignant melanoma; Neuroendocrine tumours; Non-small cell lung cancer; Pancreatic cancer; Renal cell carcinoma; Uveal melanoma
  • Phase I/II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase I Solid tumours

Most Recent Events

  • 25 Oct 2018 Syndax pharmaceuticals plans a registration trial for Non-small cell lung cancer (Second-line therapy or greater, Combination therapy) in the first half of 2019
  • 25 Oct 2018 ECOG-ACRIN completes enrolment in the phase III E2112 trial for Breast cancer in USA
  • 25 Sep 2018 Updated efficacy, pharmacodynamics and adverse events data from the phase II ENCORE 601 trial in Non-small cell lung cancer released by Syndax
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