Deferasirox - Novartis

Drug Profile

Deferasirox - Novartis

Alternative Names: CGP-72670; Deferasirox; Exjade; ICL-670; ICL-670A; Jadenu

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Novartis
  • Class Benzoic acids; Small molecules; Triazoles
  • Mechanism of Action Chelating agents; Cytochrome P 450 cyp2c8 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Iron overload
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Iron overload
  • Phase II Myelodysplastic syndromes; Thalassaemia
  • Discontinued Malaria

Most Recent Events

  • 09 Dec 2017 Efficacy and adverse events data from the phase II Kallisto trial in Myelodysplastic syndromes presented at the 59th Annual Meeting and Exposition of the American Society of Hematology (ASH-2017)
  • 15 Jul 2017 Phase-II clinical trials in Thalassaemia in Turkey (PO) (NCT02993224)
  • 05 Jul 2017 Novartis plans a phase II trial for Haemochromatosis (NCT03203850)
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