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Vandetanib - AstraZeneca

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Drug Profile

Vandetanib - AstraZeneca

Alternative Names: AZD 6474; Caprelsa; SAR 390530; Zactima; ZD 6474; Zictifa

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator AstraZeneca
  • Developer AstraZeneca; Fox Chase Cancer Center; Hoosier Cancer Research Network; Sanofi; University of Oxford
  • Class Antineoplastics; Bromobenzenes; Fluorobenzenes; Piperidines; Quinazolines; Small molecules
  • Mechanism of Action Epidermal growth factor receptor antagonists; Proto-oncogene protein c-ret inhibitors; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thyroid cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Thyroid cancer
  • Phase II Malignant melanoma; Small cell lung cancer
  • No development reported Brain metastases; Gastrointestinal cancer
  • Discontinued Biliary cancer; Breast cancer; Colorectal cancer; Head and neck cancer; Liver cancer; Malignant pleural effusion; Mesothelioma; Non-small cell lung cancer; Ovarian cancer; Prostate cancer

Most Recent Events

  • 14 Feb 2023 Genzyme completes the phase III ZEAL trial in Non-small cell lung cancer (Combination therapy, Second-line therapy or greater, Late stage disease, Metastatic disease) in USA, Argentina, Australia, Belgium, Colombia, France, Germany, Greece, Hong Kong, India, Israel, Italy, Mexico, Philippines, Portugal, South Africa, Spain, Sweden, Taiwan, Venezuela and United Kingdom (IV) (NCT00418886) (EudraCT2006-003695-35)
  • 10 May 2018 AstraZeneca suspends patient enrolment in the phase II ZACFAST trial due to drugs unavailable for Breast cancer in USA (PO) (NCT01934335)
  • 09 Dec 2017 AstraZeneca re-initiates the phase III VERIFY trial for Thyroid cancer (Late-stage disease) in USA, Brazil, China, Japan, Russia, Denmark, France, Italy, Poland, Spain, Czechia and Sweden (PO) (NCT01876784)

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