Vandetanib - AstraZeneca

Drug Profile

Vandetanib - AstraZeneca

Alternative Names: AZD 6474; Caprelsa; SAR 390530; Zactima; ZD 6474; Zictifa

Latest Information Update: 31 May 2018

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At a glance

  • Originator AstraZeneca
  • Developer AstraZeneca; Fox Chase Cancer Center; Hoosier Cancer Research Network; Sanofi; University of Oxford
  • Class Antineoplastics; Bromobenzenes; Fluorobenzenes; Piperidines; Quinazolines; Small molecules
  • Mechanism of Action Epidermal growth factor receptor antagonists; Proto oncogene protein c ret inhibitors; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Thyroid cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Thyroid cancer
  • Phase II Malignant melanoma; Small cell lung cancer
  • No development reported Brain metastases; Gastrointestinal cancer
  • Discontinued Biliary cancer; Breast cancer; Colorectal cancer; Head and neck cancer; Hepatocellular carcinoma; Malignant pleural effusion; Mesothelioma; Non-small cell lung cancer; Ovarian cancer; Prostate cancer

Most Recent Events

  • 10 May 2018 AstraZeneca suspends patient enrolment in the phase II ZACFAST trial due to drugs unavailable for Breast cancer in USA (PO) (NCT01934335)
  • 09 Dec 2017 AstraZeneca re-initiates the phase III VERIFY trial for Thyroid cancer (Late-stage disease) in USA, Brazil, China, Japan, Russia, Denmark, France, Italy, Poland, Spain, Czechia and Sweden (PO) (NCT01876784)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Gastrointestinal-cancer(Combination therapy, Late-stage disease) in USA (PO, Tablet)
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