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Drotrecogin alfa

Drug Profile

Drotrecogin alfa

Alternative Names: DrotAA; LTC-203; LY 203638; Recombinant human activated protein C; rhAPC; Xigris

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Eli Lilly
  • Developer Georgetown University; Syncor; Teijin Pharma
  • Class Anticoagulants; Antithrombotics; Blood proteins; Enzyme precursors; Recombinant proteins
  • Mechanism of Action Fibrinolytic agents; Serine endopeptidase stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Market Withdrawal Septic shock
  • Discontinued Thrombosis

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 25 Oct 2011 Discontinued - Phase-I for Septic shock in Japan (IV)
  • 25 Oct 2011 Discontinued - Registered for Septic shock in Colombia (IV)
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