Laromustine - Vion Pharmaceuticals

Drug Profile

Laromustine - Vion Pharmaceuticals

Alternative Names: 101M; Cloretazine; Onrigin; VNP 4010M; VNP40101M

Latest Information Update: 11 Sep 2018

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At a glance

  • Originator Yale University
  • Developer Vion Pharmaceuticals
  • Class Antineoplastics; Hydrazines; Small molecules; Sulfonamides
  • Mechanism of Action Alkylating agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Suspended Acute myeloid leukaemia; Glioma; Myelodysplastic syndromes
  • Discontinued Chronic lymphocytic leukaemia

Most Recent Events

  • 27 Aug 2018 Vion Pharmaceuticals terminates a phase I/II trial for Myelodysplastic syndromes and Acute myeloid leukaemia (In the elderly, Combination therapy) in USA (IV) (NCT00655395)
  • 24 Jun 2018 Biomarkers information updated
  • 27 Feb 2010 Vion receives an FDA response relating to the SPA for the phase II/III trial in Acute myeloid leukaemia
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