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Aflibercept - Bayer/Regeneron Pharmaceuticals/Sanofi

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Drug Profile

Aflibercept - Bayer/Regeneron Pharmaceuticals/Sanofi

Alternative Names: aflibercept [genetical recombination]; AVE-0005; BAY-865321; EYLEA; Eylea; EYLEA HD; EYLEA® solution for intravitreal injection; Eylia; REGN3; Vascular endothelial growth factor Trap; Vascular endothelial growth factor Trap-R1R2; VEGF Trap (R1R2); VEGF Trap-Eye; Wetlia; Zaltrap; Ziv-aflibercept

Latest Information Update: 20 Dec 2024

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At a glance

  • Originator Regeneron Pharmaceuticals
  • Developer Bayer; Bayer HealthCare Pharmaceuticals; Bayer Yakuhin; Centre Oscar Lambret; GERCOR; Greater Houston Retina Research; Guys Hospital; Hellenic Cooperative Oncology Group; Moorfields Eye Hospital; National Cancer Institute (USA); Regeneron Pharmaceuticals; Roche; Sanofi; sanofi-aventis; Tufts Medical Center; University of Ulm
  • Class Antineoplastics; Eye disorder therapies; Immunoglobulin Fc fragments; Immunoglobulin fragments; Recombinant fusion proteins
  • Mechanism of Action Placenta growth factor inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glaucoma; Retinopathy of prematurity
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Branch retinal vein occlusion; Central retinal vein occlusion; Choroidal neovascularisation; Colorectal cancer; Diabetic macular oedema; Diabetic retinopathy; Glaucoma; Retinal oedema; Retinopathy of prematurity; Wet age-related macular degeneration
  • Phase III Polypoidal choroidal vasculopathy
  • Phase II Central serous chorioretinopathy; Graves ophthalmopathy; Retinal disorders
  • No development reported Malignant ascites; Non-Hodgkin's lymphoma; Ovarian cancer; Solid tumours
  • Discontinued Non-small cell lung cancer; Pancreatic cancer; Prostate cancer

Most Recent Events

  • 17 Dec 2024 Regeneron Pharmaceuticals plans to submit supplementary biologics license application to the US Food and Drug Administration in Retinal oedema in the first quarter of 2025
  • 17 Dec 2024 Safety and efficacy data from the phase III QUASAR trial in Retinal oedema released by Regeneron Pharmaceuticals
  • 31 Oct 2024 Updated efficacy data from the phase II/III PHOTON trial in Eye disorders released by Regeneron Pharmaceuticals

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