Aflibercept - Regeneron Pharmaceuticals/Bayer/Sanofi

Drug Profile

Aflibercept - Regeneron Pharmaceuticals/Bayer/Sanofi

Alternative Names: AVE-0005; BAY-865321; Eylea; Eylia; Vascular endothelial growth factor Trap; Vascular endothelial growth factor Trap-R1R2; VEGF Trap (R1R2); VEGF Trap-Eye; Zaltrap; Ziv-aflibercept

Latest Information Update: 20 Apr 2018

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At a glance

  • Originator Regeneron Pharmaceuticals
  • Developer Bayer HealthCare Pharmaceuticals; Bayer Yakuhin; Centre Oscar Lambret; GERCOR; Guys Hospital; Hellenic Cooperative Oncology Group; Moorfields Eye Hospital; National Cancer Institute (USA); Regeneron Pharmaceuticals; Sanofi; sanofi-aventis; University of Ulm
  • Class Eye disorder therapies; Recombinant fusion proteins
  • Mechanism of Action Placenta growth factor inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Branch retinal vein occlusion; Central retinal vein occlusion; Choroidal neovascularisation; Colorectal cancer; Diabetic macular oedema; Wet age-related macular degeneration
  • Registered Diabetic retinopathy
  • Phase III Glaucoma; Polypoidal choroidal vasculopathy
  • Phase II Central serous chorioretinopathy
  • No development reported Malignant ascites; Non-Hodgkin's lymphoma; Ovarian cancer; Solid tumours
  • Discontinued Non-small cell lung cancer; Pancreatic cancer; Prostate cancer

Most Recent Events

  • 19 Mar 2018 Regeneron Pharmaceuticals announces intention to submit sBLA to US FDA for Diabetic retinopathy in 2018
  • 19 Mar 2018 Interim efficacy and adverse events data from a phase III PANORAMA trial in diabetic retinopathy released by Regeneron Pharmaceuticals
  • 14 Feb 2018 Registered for Diabetic macular oedema in China (Intravitreous)
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