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Aflibercept - Bayer/Regeneron Pharmaceuticals/Sanofi

Drug Profile

Aflibercept - Bayer/Regeneron Pharmaceuticals/Sanofi

Alternative Names: AVE-0005; BAY-865321; EYLEA; Eylea; Eylia; Vascular endothelial growth factor Trap; Vascular endothelial growth factor Trap-R1R2; VEGF Trap (R1R2); VEGF Trap-Eye; Zaltrap; Ziv-aflibercept

Latest Information Update: 08 Nov 2019

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At a glance

  • Originator Regeneron Pharmaceuticals
  • Developer Bayer HealthCare Pharmaceuticals; Bayer Yakuhin; Centre Oscar Lambret; GERCOR; Greater Houston Retina Research; Guys Hospital; Hellenic Cooperative Oncology Group; Moorfields Eye Hospital; National Cancer Institute (USA); Regeneron Pharmaceuticals; Sanofi; sanofi-aventis; Tufts Medical Center; University of Ulm
  • Class Antineoplastics; Eye disorder therapies; Recombinant fusion proteins
  • Mechanism of Action Placenta growth factor inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Branch retinal vein occlusion; Central retinal vein occlusion; Choroidal neovascularisation; Colorectal cancer; Diabetic macular oedema; Diabetic retinopathy; Wet age-related macular degeneration
  • Phase III Glaucoma; Polypoidal choroidal vasculopathy; Retinopathy of prematurity
  • Phase II Central serous chorioretinopathy; Retinal disorders; Retinal oedema
  • No development reported Malignant ascites; Non-Hodgkin's lymphoma; Ovarian cancer; Solid tumours
  • Discontinued Non-small cell lung cancer; Pancreatic cancer; Prostate cancer

Most Recent Events

  • 15 Oct 2019 Regeneron Pharmaceuticals and Bayer plan a phase II CANDELA trial for Wet age-related macular degeneration (Treatment-naive) (Intravitreal, Injection) in October 2019 (NCT04126317)
  • 24 Sep 2019 Bayer completes the phase III VIOLET trial in Diabetic macular oedema in Slovakia, Hungary, Germany, Spain, Austria, Lithuania, Czech Republic, Italy, Poland, Portugal, the UK, France, Canada and Switzerland (Intravitreous) (NCT02818998)
  • 16 Aug 2019 The US FDA approves the pre-filled syringe formulation of aflibercept
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