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MKC 1

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Drug Profile

MKC 1

Alternative Names: MKC-1; R 440; RO 31-7453

Latest Information Update: 18 Jun 2014

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At a glance

  • Originator Roche
  • Developer CASI Pharmaceuticals
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Apoptosis stimulants; Hypoxia-inducible factor 1 alpha inhibitors; Importin beta protein inhibitors; Mitosis inhibitors; MTOR protein inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Suspended Breast cancer; Haematological malignancies; Leukaemia; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Solid tumours

Most Recent Events

  • 16 Jun 2014 EntreMed is now called CASI Pharmaceuticals
  • 10 Nov 2008 MKC 1 meets primary efficacy endpoint in open-label phase I/II study in non-small cell lung cancer
  • 03 Jun 2008 Interim efficacy and adverse events data from a phase I/II trial in advanced Non-small cell lung cancer presented at the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO-2008)

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