Trastuzumab emtansine - Immunogen/Roche

Drug Profile

Trastuzumab emtansine - Immunogen/Roche

Alternative Names: Ado-trastuzumab emtansine; DM1-trastuzumab immunoconjugate; Kadcyla; PRO-132365; R3502; RG 3502; RO 5304020; T-DM1; Trastuzumab-DM1; Trastuzumab-DM1 immunoconjugate; Trastuzumab-MCC-DM1; Trastuzumab-MCC-DM1 antibody-drug conjugate; Trastuzumab–SMCC–DM1 conjugate

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Genentech; ImmunoGen
  • Developer Chugai Pharmaceutical; Genentech; Memorial Sloan-Kettering Cancer Center; Roche; University College London; University of Miami
  • Class Antineoplastics; Drug conjugates; Immunoconjugates; Immunotoxins; Macrolides; Maytansinoids; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Immunomodulators; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Marketed Breast cancer
  • Phase II/III Gastric cancer
  • Phase II Bladder cancer; Lung cancer; Non-small cell lung cancer; Solid tumours; Urogenital cancer

Most Recent Events

  • 23 Jan 2018 Chugai completes the phase Ib MARIA15-01 trial in Breast cancer (Combination therapy, Second-line therapy or greater, Metastatic disease) in Japan (UMIN000018383)
  • 05 Dec 2017 Efficacy data from the phase III KRISTINE trial in Breast cancer presented at the 40th Annual San Antonio Breast Cancer Symposium (SABCS-2017)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Gastric-cancer(Combination therapy, Metastatic disease, Second-line therapy or greater) in Argentina (IV, Infusion)
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