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Pegargiminase - Polaris Pharmaceuticals

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Drug Profile

Pegargiminase - Polaris Pharmaceuticals

Alternative Names: ADI-PEG; ADI-PEG 20; ADI-SS PEG; ADZODI; Arginine deiminase pegylated; Arginine deiminase-PEG; Hepacid; Melanocid; PEG arginine deiminase; Pegylated arginine deiminase - Polaris Group

Latest Information Update: 13 Feb 2026

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At a glance

  • Originator Phoenix Pharmacologics
  • Developer Barts and The London School of Medicine and Dentistry; Memorial Sloan-Kettering Cancer Center; Polaris Pharmaceuticals; University of Miami; Washington University School of Medicine
  • Class Antineoplastics; Hepatoprotectants; Hydrolases; Polyethylene glycols; Proteins; Radiosensitisers
  • Mechanism of Action Arginine deiminase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant-mesothelioma; Liver cancer; Malignant melanoma
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Preregistration Malignant-mesothelioma
  • Phase III Leiomyosarcoma; Liver cancer; Soft tissue sarcoma
  • Phase II/III Glioblastoma
  • Phase II Acute myeloid leukaemia; Malignant melanoma; Non-alcoholic steatohepatitis; Non-Hodgkin's lymphoma; Small cell lung cancer
  • No development reported Bladder cancer; Breast cancer; Cancer; Gastrointestinal cancer; Head and neck cancer; Lymphoma; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer; Renal cell carcinoma; Sarcoma; Solid tumours; Uveal melanoma; Viral infections

Most Recent Events

  • 05 Feb 2026 University of California plans a phase I/II trial for Glioblastoma and Glioma in the US (IM) in March 2026(NCT07389278)
  • 06 Dec 2025 Efficacy and adverse events data from a phase I trial in Acute myeloid leukemia presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2025)
  • 22 Jul 2025 Pegargiminase licensed to Bioprofarma Bago in Latin America and Argentina

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