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UB 421

Drug Profile

UB 421

Alternative Names: dB4; dB4C7 mAb; mAb B4; UB421

Latest Information Update: 28 Nov 2017

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At a glance

  • Originator United Biomedical
  • Developer United Biomedical; United BioPharma
  • Class Antiretrovirals; Monoclonal antibodies
  • Mechanism of Action HIV fusion inhibitors; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II HIV-1 infections

Most Recent Events

  • 23 Nov 2018 United BioPharma plans a phase II trial in HIV-1 infections (Combination therapy, Adjunctive therapy) (IV, Infusion) in March 2019 (NCT03743376)
  • 30 May 2018 United BioPharma plans a phase IIb/III trial for HIV-1 infection (Adjunctive therapy, Second-line therapy or greater) in USA (IV, Infusion) in September 2018 (NCT03164447)
  • 28 Nov 2017 United Biopharma files IND applications with regulatory authorities in China and Thailand for a phase III trial in HIV-1 infections prior to November 2017
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