Drug Profile


Alternative Names: BA503; CY-503; ME-503; Mistletoe lectin recombinant; Recombinant mistletoe lectin; Recombinant viscumin; Recombinant viscumine; rViscumin; Viscum ribosome inactivating protein

Latest Information Update: 21 Jul 2016

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At a glance

  • Originator VISCUM AG
  • Developer MELEMA Pharma GmbH
  • Class Antineoplastics; Biological toxins; Lectins; Plant proteins
  • Mechanism of Action 28S ribosomal RNA inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase II Colorectal cancer; Malignant melanoma

Most Recent Events

  • 16 Apr 2016 Phase II development for aviscumine is ongoing in Germany and Autria
  • 16 Apr 2016 Final Efficacy data from a phase II trial in Melanoma presented at the 107th Annual Meeting of the American Association for Cancer Research (AACR -2016)
  • 31 Aug 2012 Cytavis Biopharma terminates a phase II trial in Colorectal cancer (metastatic disease, second-line or greater therapy) in Germany and Austria due to poor recruitment (NCT00932724)
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