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Ispinesib - Cytokinetics

Drug Profile

Ispinesib - Cytokinetics

Alternative Names: 715992; CK 0238273; Ispinesib mesilate; Ispinesib mesylate; SB-715992; SB-715992-S

Latest Information Update: 08 May 2019

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At a glance

  • Originator Cytokinetics
  • Class Antineoplastics; Benzamides; Quinazolines; Small molecules
  • Mechanism of Action KIF11 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Suspended Breast cancer; Colorectal cancer; Haematological malignancies; Renal cancer; Solid tumours
  • Discontinued Head and neck cancer; Liver cancer; Malignant melanoma; Non-small cell lung cancer; Ovarian cancer; Prostate cancer

Most Recent Events

  • 26 Apr 2019 Discontinued - Phase-I/II for Breast cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in Peru (IV) (NCT00607841)
  • 24 Jun 2018 Biomarkers information updated
  • 20 Jul 2012 The National Cancer Institute, in collaboration with GlaxoSmithKline, completes a phase II trial in Renal cancer in the US (NCT00354250)
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