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Research programme: cyclin-dependent kinase inhibitors - Cyclacel Pharmaceuticals

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Drug Profile

Research programme: cyclin-dependent kinase inhibitors - Cyclacel Pharmaceuticals

Alternative Names: 2-Anilino-4-(thiazol-5-yl)-pyrimidine - Cyclacel Pharmaceuticals; CCT-68127; CYC 11056; CYC400 series - Cyclacel Pharmaceuticals; Second-generation CDK inhibitors - Cyclacel Pharmaceuticals; Tri-substituted purines - Cyclacel Pharmaceuticals

Latest Information Update: 10 Mar 2023

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At a glance

  • Originator Cyclacel Pharmaceuticals
  • Class Purines; Pyrimidines; Small molecules
  • Mechanism of Action Cyclin-dependent kinase 2 inhibitors; Cyclin-dependent kinase 5 inhibitors; Cyclin-dependent kinase 9 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Cancer; Glomerulonephritis; Neuroblastoma; Precursor cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 10 Mar 2023 Discontinued - Preclinical for Neuroblastoma in United Kingdom (PO)
  • 23 Feb 2023 Discontinued - Preclinical for Acute myeloid leukaemia in United Kingdom (PO)
  • 23 Feb 2023 Discontinued - Preclinical for Cancer in United Kingdom (IV)

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