Rilonacept - Kiniksa Pharmaceuticals/Regeneron Pharmaceuticals

Drug Profile

Rilonacept - Kiniksa Pharmaceuticals/Regeneron Pharmaceuticals

Alternative Names: Arcalyst; IL-1 Trap; IL-1 Trap - Regeneron; Interleukin-1 Trap - Regeneron; KPL 914; RGN 303

Latest Information Update: 22 May 2018

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At a glance

  • Originator Regeneron Pharmaceuticals
  • Developer Boston University; Kiniksa Pharmaceuticals; Regeneron Pharmaceuticals
  • Class Anti-inflammatories; Antirheumatics; Recombinant fusion proteins
  • Mechanism of Action Caspase 1 inhibitors; Interleukin 1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cryopyrin-associated periodic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cryopyrin-associated periodic syndromes
  • Phase II Cardiovascular disorders
  • Phase I/II Systemic scleroderma
  • Discontinued Anaemia; Gout; Juvenile rheumatoid arthritis; Osteoarthritis; Polymyalgia rheumatica; Rheumatoid arthritis

Most Recent Events

  • 22 May 2018 Kiniksa Pharmaceuticals plans a phase III trial for Cardiovascular disorders (recurrent pericarditis) in 2018 (Kiniksa Pharmaceuticals pipeline, May 2018)
  • 27 Apr 2018 Phase-II clinical trials in Cardiovascular disorders in USA (SC)
  • 11 Aug 2017 Regeneron Pharmaceuticals completes a phase I/II trial in Systemic scleroderma in USA (SC) (NCT01538719)
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