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Nitric oxide synthase therapy - MaxCyte/Northern Therapeutics

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Drug Profile

Nitric oxide synthase therapy - MaxCyte/Northern Therapeutics

Alternative Names: Aurora-GT™; eNOS transfected EPCs - Northern Therapeutics; Pulmonary hypertension gene therapy - MaxCyte/United Therapeutics; SAPPHIRE Aurora-GT™ eNOS Gene Therapy

Latest Information Update: 12 Feb 2025

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At a glance

  • Originator MaxCyte; Northern Therapeutics
  • Class Cell therapies; Gene therapies
  • Mechanism of Action Cell replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Pulmonary arterial hypertension

Most Recent Events

  • 25 Jan 2025 Northern Therapeutics and Ottawa Hospital Research Institute terminates the phase II/III SAPPHIRE trial in Pulmonary arterial hypertension in Canada (IV) due to lower than anticipated enrollment (NCT03001414)
  • 16 Nov 2024 Efficacy and adverse events data from the phase II/III SAPPHIRE trial in Pulmonary arterial hypertension presented at the American Heart Association Scientific Sessions 2024 (AHA-2024)
  • 29 Nov 2022 Nitric oxide synthase gene therapy is still in phase II development for Pulmonary arterial hypertension in Canada (IV) (NCT03001414)

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