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Methylnaltrexone bromide - Bausch Health Companies/Progenics Pharmaceuticals

Drug Profile

Methylnaltrexone bromide - Bausch Health Companies/Progenics Pharmaceuticals

Alternative Names: Methyl-naltrexone hydrobromide; Methylnaltrexonium; MNTX; MNTX 302; MOA-728; MRZ 2663BR; MRZ-2663; N-methylnaltrexone bromide; Naltrexone MB; Naltrexone methobromide; Naltrexone methylbromide; Naltrexonium methiodide; ONO-3849; Quaternary ammonium naltrexone; Relistor; Relistor Oral

Latest Information Update: 19 Jul 2019

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At a glance

  • Originator University of Chicago
  • Developer Glycyx Pharma Ventures; Ono Pharmaceutical; Progenics Pharmaceuticals; Salix Pharmaceuticals
  • Class Morphine derivatives; Quaternary ammonium compounds; Small molecules
  • Mechanism of Action Opioid mu receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes - Constipation

Highest Development Phases

  • Marketed Constipation
  • Research Pancreatic cancer
  • Discontinued Postoperative ileus; Urination disorders

Most Recent Events

  • 05 Nov 2019 Bausch Health Americas plans a phase III extension study in Pancreatic cancer (Late-stage disease) in February 2020 (PO)(NCT04151719)
  • 11 Sep 2019 Bausch Health Americas plans a phase II/III trial in Pancreatic cancer (Late-stage disease, Inoperable/Unresectable) (SAL-REL2042; NCT04083651)
  • 17 Jul 2019 US District Court of New Jersey upholds the validity and determined Actavis' infringement of patent protecting methylnaltrexone bromide tablets
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