Riociguat - Bayer

Drug Profile

Riociguat - Bayer

Alternative Names: Adempas; BAY-32521; BAY-63-2521

Latest Information Update: 13 Apr 2018

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At a glance

  • Originator Bayer
  • Class 2 ring heterocyclic compounds; Carbamates; Fluorobenzenes; Pyrazoles; Pyridines; Pyrimidines; Small molecules; Vascular disorder therapies
  • Mechanism of Action Guanylate cyclase stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Systemic scleroderma; Pulmonary hypertension; Pulmonary arterial hypertension
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Pulmonary arterial hypertension; Pulmonary hypertension
  • Phase II Cystic fibrosis; Raynaud's disease; Systemic scleroderma

Most Recent Events

  • 10 Apr 2018 Merck has patent protection for riociguat in USA, Europe and Japan
  • 10 Oct 2017 Bayer terminates phase II trial in Cystic fibrosis in USA, Canada, Germany, the Netherlands, United Kingdom, Belgium, France, Greece and Italy, based on multiple factors, including the design of part 2 is no longer appropriate (NCT02170025)
  • 09 Sep 2017 Efficacy and adverse events data from the phase IIb RISE-IIP trial in Pulmonary hypertension presented at the 27th Annual Congress of the European Respiratory Society (ERS-2017)
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