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Pertuzumab - Genentech/Roche

Drug Profile

Pertuzumab - Genentech/Roche

Alternative Names: Anti-2C4 monoclonal antibody; Omnitarg; Perjeta; R-1273; RG-1273; rhuMab-2C4; rhuMAb2C4; Ro 436-8451/F01; RO-4368451-F01; RO4368451

Latest Information Update: 16 Jan 2019

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At a glance

  • Originator Genentech; Roche
  • Developer Chugai Pharmaceutical; Dana-Farber Cancer Institute; FONDAZIONE DEL PIEMONTE PER L'ONCOLOGIA IRCC DI CANDIOLO; Genentech; International Breast Cancer Study Group; Japan Breast Cancer Research Group; Medica Scientia Innovation Research; Roche; West German Study Group
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Dimerisation inhibitors; ERBB 2 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer
  • Phase III Ovarian cancer
  • Phase II Brain metastases; Colorectal cancer
  • Discontinued Gastric cancer; Non-small cell lung cancer; Prostate cancer

Most Recent Events

  • 20 Dec 2018 Roche initiates the phase III IMpassion050 trial for Breast Cancer (Combination therapy) in Germany, Italy, South Korea, Czech Republic (IV) (NCT03726879)
  • 17 Dec 2018 Registered for Breast cancer (Combination therapy, Early-stage disease, Adjuvant therapy) in China (IV)
  • 04 Dec 2018 Efficacy and adverse events data from the phase III PEONY trial in Breast cancer presented at the 41st Annual San Antonio Breast Cancer Symposium (SABCS-2018)
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